Get data
Use mSigPortal and TCGA/GDC resources, local MAF files, and matrix imports.
mSigSDK
Browser-native mutational signature analysis from spectra to reports.
Import one ES module for mSigPortal access, spectra validation, known-signature fitting, browser-sized NMF, uncertainty-aware QC, report-ready visualizations, and reproducible exports.
Static
Browser module
Runs in notebooks, static pages, and local browser workflows.
Evidence
QC attached
Uncertainty, residuals, thresholds, and provenance stay with outputs.
Interop
Tool handoffs
Adapters prepare files for established signature packages.
Report
Figure outputs
SBS96, exposure, residual, similarity, and summary plots.
Hosted notebooks use public or bundled demo data. Use the SDK in your own environment for private data, large cohorts, and production validation; compatible external engines stay connected through adapters and optional browser runtimes.
Capabilities
From spectra to report
mSigSDK supports browser-based mutational-signature review from public or local inputs through validation, fitting, quality checks, visual review, and exportable reports. External tools remain separate engines; mSigSDK prepares handoff files and records provenance for those workflows.
Check inputs
Validate spectra, signatures, exposures, contexts, and MAF fields before analysis.
Run review
Fit known signatures, review panel/WES results, summarize cohorts, and run exploratory NMF.
Share outputs
Export QC figures, JSON/HTML reports, TSV files, handoff bundles, and provenance.
Example notebooks
Notebook workflows
Each notebook shows one SDK task with public or bundled demo inputs. Inspect the code and outputs here; run private datasets and large cohorts in your own environment.
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